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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually focused on the practical aspects of research design, like recruitment and consent in adherence, as well as the use of commonly available equipment.

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A practical trial that employs different investigators and participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for pragmatic trials to be reliable and lessen the chance of bias, is also necessary. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials aim to mimic real-life settings and 프라그마틱 슬롯버프 achieve maximum external validity. They are typically commissioned by policy makers and practitioners to aid in their decision-making. They can be used to determine the cause-effect relationship of an intervention and its results. However, they should not be used as a substitute for the use of explanation trials.

The concept of pragmatism is controversial and there are concerns regarding whether pragmatic trials could replace explanatory tests or if they are a complement to them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis as well as pragmatic trials, which guide the practice and policy decisions. They also suggested an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the characteristics of a practical trial, including the recruitment process, the design and implementation of the intervention, as well as follow-up.

There is a positive increase in the number of pragmatic trials that have been published. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are shown in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to note that the majority of these trials were conducted in primary care settings.