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Studies designed to provide insight into clinical practice in the real world are known as pragmatic trials. They are often characterized as a focus on the practical aspects of designing a study which include the recruitment process and consent, adhering and the use of routinely available equipment.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and had participants from different geographic areas. This type of heterogeneity is required for practical trials to be valid and also helps reduce bias in the results. However excessive heterogeneity could lead to problems with the design of the trial.

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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically requested by practitioners and policymakers to help inform their decisions. They can also be a great method to determine the cause-effect relationship between an intervention and its results. However, they should not, be used to replace explanation studies.

The idea of pragmatism is controversial, 프라그마틱 정품확인 무료스핀 (look at here) and there are questions about whether pragmatic trials can be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm the validity of a physiological or clinical hypothesis, and pragmatic trials, which inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 This tool tried to define the elements of a pragmatic study, including recruitment, design, implementation of the intervention and its follow-up.

There is an encouraging trend in the number of pragmatic trials that are published. A recent Medline search using the words naturalistic and pragmatic, restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This is a sign that the health science community is becoming more acquaint to the subject of pragmatic thinking. It is important to keep in mind that the majority of studies were conducted in primary care settings.